| Pack Size | Single Vial, 10-Pack |
|---|
N-Acetyl Semax Amidate is a chemically stabilised analogue of Semax, a heptapeptide derived from the ACTH(4-7) fragment. N-terminal acetylation and C-terminal amidation are added to slow enzymatic degradation, extending the peptide's persistence relative to native Semax. It is studied in neuropharmacology research on cognition and neuroprotection. Every batch is independently third-party tested by HPLC for purity and mass spectrometry for identity, to a minimum of 99 percent purity. Supplied as a lyophilized powder for laboratory research use only.
Description
Semax is a synthetic heptapeptide combining the ACTH(4-7) sequence Met-Glu-His-Phe with the C-terminal tripeptide Pro-Gly-Pro, giving the sequence Met-Glu-His-Phe-Pro-Gly-Pro. The Pro-Gly-Pro terminus already confers resistance to some peptidases. N-Acetyl Semax Amidate adds two further modifications — acetylation of the N-terminus and amidation of the C-terminus — that further reduce susceptibility to aminopeptidase and carboxypeptidase cleavage, producing a longer-lasting research analogue.
In the research-supply context, N-Acetyl Semax Amidate is used as a stabilised tool for studying the same neuropharmacology as Semax. It is provided strictly as a research-grade reagent for laboratory benchwork.
Mechanism in research literature
Semax and its analogues are studied as neuromodulatory peptides. The literature associates Semax with modulation of the brain-derived neurotrophic factor (BDNF) system and its receptor signalling, effects on the dopaminergic and serotonergic systems, and influence on neurotrophin expression. These actions underlie its investigation in cognition, attention, and neuroprotection models. As a metabolically stabilised analogue, N-Acetyl Semax Amidate is studied for the same pathways with a longer functional window than native Semax.
The acetyl and amide modifications are pharmacokinetic rather than pharmacodynamic: they are intended to change how quickly the peptide is degraded, not to introduce a new mechanism. Comparative study against native Semax is the standard way the stabilised analogue is examined.
Studied properties
Documented areas of research for Semax and its analogues include: BDNF-system modulation; neuroprotection in ischaemia and stress models; cognitive, attention, and memory endpoints; and neurotrophin and monoamine signalling. These describe the published research landscape and are provided for scientific context only. They are not claims of efficacy. Ronin Peptides supplies N-Acetyl Semax Amidate exclusively as a research-grade reagent and provides no dosing protocols or therapeutic recommendations.
Compound specifications
| Compound | N-Acetyl Semax Amidate |
|---|---|
| Sequence | Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 |
| Length | 7 amino acids (N-acetylated, C-terminal amide) |
| Parent | Semax (Met-Glu-His-Phe-Pro-Gly-Pro), ACTH(4-7) analogue |
| Modification | N-terminal acetylation + C-terminal amidation for metabolic stability |
| Class | Neuromodulatory peptide (stabilised analogue) |
| Form | Lyophilized white-to-off-white powder |
| Solubility | Bacteriostatic water; sterile water for injection |
| Vial contents | 30 mg peptide, sealed amber-glass vial under inert gas |
| Purity | ≥99% by HPLC (verified per batch by a third-party analytical lab) |
Storage and handling
Store unopened lyophilized vials dry and cold; long-term storage should be at or below −20 °C, protected from light and moisture. Once reconstituted, keep refrigerated at 2–8 °C and use within a few weeks; avoid repeated freeze–thaw cycles. The methionine residue is sensitive to oxidation. Bring vials to room temperature before opening.
Compare with similar compounds
N-Acetyl Semax Amidate is the metabolically stabilised counterpart of native Semax; the two are studied side by side to examine the effect of the acetyl and amide modifications on persistence. It is frequently studied alongside N-Acetyl Selank Amidate, a similarly stabilised analogue of the anxiolytic peptide Selank, since the two are often paired in neuropharmacology research covering complementary cognitive and anxiolytic endpoints.
Reconstitution and laboratory handling
A 30 mg vial of N-Acetyl Semax Amidate reconstituted with 3 mL of bacteriostatic water yields a final concentration of 10 mg/mL, or 10,000 mcg/mL. Other diluent volumes scale linearly: 2 mL gives 15 mg/mL, 6 mL gives 5 mg/mL.
- Bring both vials to room temperature before opening.
- Sanitise both rubber stoppers with an alcohol swab.
- Pull the chosen diluent volume into a sterile transfer syringe.
- Direct the water against the inner wall of the peptide vial as it is injected — never onto the lyophilized cake.
- Invert slowly or swirl gently until dissolved. Do not vortex or shake.
- Refrigerate at 2–8 °C.
Frequently asked questions
What is N-Acetyl Semax Amidate?
It is a chemically stabilised analogue of the heptapeptide Semax, carrying N-terminal acetylation and C-terminal amidation to slow enzymatic degradation. It is studied in the same neuropharmacology research as Semax.
How does it differ from regular Semax?
The acetyl and amide modifications are pharmacokinetic: they extend the peptide's persistence against peptidase cleavage. The underlying mechanism is the same as native Semax.
What is the regulatory status?
Supplied as a research-grade reagent for laboratory use only, not for human or veterinary use.
How is it verified?
Each batch passes through an independent third-party analytical lab for HPLC purity and mass-spectrometry identity confirmation, to a minimum of 99 percent purity.
How do I receive the COA for my batch?
A certificate of analysis is available for your specific batch on request, tied to your lot.
References
- Glazova NY et al. Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides. 2021. PMID 33418449.
- Dolotov OV et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain research. 2006. PMID 16996037.
- Medvedeva EV et al. Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats. Molecular genetics and genomics : MGG. 2017. PMID 28255762.
