| Pack Size | Single Vial, 10-Pack |
|---|
Intranasal-spray format. Ships unreconstituted: lyophilized peptide in a 10 mL spray bottle, reconstituted with the included 0.3% potassium sorbate solution. Research use only; not for human use.
N-Acetyl Selank Amidate is a chemically stabilised analogue of Selank, a synthetic heptapeptide derived from the immunopeptide tuftsin. N-terminal acetylation and C-terminal amidation slow enzymatic degradation, extending persistence relative to native Selank. It is studied in neuropharmacology research on anxiolytic and cognitive endpoints. Every batch is independently third-party tested by HPLC for purity and mass spectrometry for identity, to a minimum of 99 percent purity. Supplied as a lyophilized powder for laboratory research use only.
Description
Selank is a synthetic heptapeptide built from the tuftsin fragment Thr-Lys-Pro-Arg extended with the C-terminal tripeptide Pro-Gly-Pro, giving the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. N-Acetyl Selank Amidate adds acetylation of the N-terminus and amidation of the C-terminus, modifications that reduce cleavage by aminopeptidases and carboxypeptidases and yield a longer-lasting research analogue.
In the research-supply context, N-Acetyl Selank Amidate is used as a stabilised tool for studying the same neuropharmacology and immunomodulatory activity as Selank. It is provided strictly as a research-grade reagent for laboratory benchwork.
Mechanism in research literature
Selank and its analogues are studied as anxiolytic and neuromodulatory peptides. The literature associates Selank with modulation of the GABAergic system, effects on the balance of monoamine neurotransmitters, influence on the expression of brain-derived neurotrophic factor, and immunomodulatory activity inherited from its tuftsin origin, including effects on interleukin expression. These actions underlie its investigation in anxiety, stress, and cognition models. As a metabolically stabilised analogue, N-Acetyl Selank Amidate is studied for the same pathways over a longer functional window than native Selank.
The acetyl and amide modifications are pharmacokinetic rather than pharmacodynamic; comparative study against native Selank is the standard way the stabilised analogue is examined.
Studied properties
Documented areas of research for Selank and its analogues include: anxiolytic endpoints; GABAergic and monoamine modulation; BDNF-system effects; immunomodulation via interleukin regulation; and cognition and stress-resilience models. These describe the published research landscape and are provided for scientific context only. They are not claims of efficacy. Ronin Peptides supplies N-Acetyl Selank Amidate exclusively as a research-grade reagent and provides no dosing protocols or therapeutic recommendations.
Compound specifications
| Compound | N-Acetyl Selank Amidate |
|---|---|
| Sequence | Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2 |
| Length | 7 amino acids (N-acetylated, C-terminal amide) |
| Parent | Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), tuftsin analogue |
| Modification | N-terminal acetylation + C-terminal amidation for metabolic stability |
| Class | Anxiolytic / neuromodulatory peptide (stabilised analogue) |
| Form | Lyophilized white-to-off-white powder |
| Solubility | Bacteriostatic water; sterile water for injection |
| Peptide fill | 30 mg peptide, lyophilized in a 10 mL intranasal-spray bottle; reconstituted with the included 0.3% potassium sorbate solution |
| Purity | ≥99% by HPLC (verified per batch by a third-party analytical lab) |
Storage and handling
Store unopened lyophilized vials dry and cold; long-term storage should be at or below −20 °C, protected from light and moisture. Once reconstituted, keep refrigerated at 2–8 °C and use within a few weeks; avoid repeated freeze–thaw cycles. Bring vials to room temperature before opening.
Compare with similar compounds
N-Acetyl Selank Amidate is the metabolically stabilised counterpart of native Selank; the two are studied side by side to examine the effect of the acetyl and amide modifications on persistence. It is frequently studied alongside N-Acetyl Semax Amidate, the stabilised analogue of the nootropic peptide Semax, since the two are often paired in neuropharmacology research covering complementary anxiolytic and cognitive endpoints.
Intranasal reconstitution and use
This nasal spray ships unreconstituted. The peptide is supplied lyophilized in a 10 mL intranasal-spray bottle together with the 0.3% potassium sorbate solution required to reconstitute it (included) — potassium sorbate acts as a preservative suited to an intranasal solution. Add the full 10 mL of the included solution to reconstitute; the resulting concentration is the bottle’s peptide load divided by 10 mL. A typical metered intranasal actuation delivers approximately 0.1 mL, so each spray delivers roughly one-hundredth of the total peptide load.
- Bring the spray bottle and the included 0.3% potassium sorbate solution to room temperature.
- Sanitise the stoppers with an alcohol swab.
- Add the full 10 mL of the included 0.3% potassium sorbate solution to the lyophilized peptide, directing the liquid against the inner wall — never onto the lyophilized cake.
- Invert slowly or swirl gently until dissolved. Do not vortex or shake.
- Attach the spray pump to the bottle and prime it before first use.
- Store the reconstituted solution refrigerated at 2–8 °C and avoid repeated freeze–thaw cycles.
Frequently asked questions
What is N-Acetyl Selank Amidate?
It is a chemically stabilised analogue of the heptapeptide Selank, carrying N-terminal acetylation and C-terminal amidation to slow enzymatic degradation. It is studied in the same anxiolytic and neuromodulatory research as Selank.
How does it differ from regular Selank?
The acetyl and amide modifications are pharmacokinetic: they extend persistence against peptidase cleavage. The underlying mechanism is the same as native Selank.
What is the regulatory status?
Supplied as a research-grade reagent for laboratory use only, not for human or veterinary use.
How is it verified?
Each batch passes through an independent third-party analytical lab for HPLC purity and mass-spectrometry identity confirmation, to a minimum of 99 percent purity.
How do I receive the COA for my batch?
A certificate of analysis is available for your specific batch on request, tied to your lot.
References
- Zozulya AA, et al. Efficacy and safety of Selank in the therapy of anxiety disorders. Zhurnal Nevrologii i Psikhiatrii. 2008.
- Kolomin T, et al. Transcriptomic response of rat hippocampus to Selank. Journal of Molecular Neuroscience. 2014.
- Semenova TP, et al. Neuroprotective and anxiolytic effects of Selank. Bulletin of Experimental Biology and Medicine. 2010.
