What is the typical Epithalon dose?
Preclinical Epithalon research protocols in the Khavinson-group literature typically use 1-10 mcg per dose in rodent models, administered intranasally or subcutaneously across multi-week to multi-month protocol durations. The compound’s small size and Russian-research-group concentration shape both the dose framework and the available comparison data.
What the research literature says
The Epithalon dose framework derives from the Khavinson research program at the St. Petersburg Institute of Bioregulation and Gerontology. The Khavinson lifespan-extension work in Drosophila melanogaster used invertebrate-model dose tiers (PMID 11087911). The Anisimov colon carcinogenesis work in rats (PMID 12049808) and the Kossoy spontaneous-carcinogenesis work in C3H/He mice (PMID 16634527) used mammalian-model dose tiers in the low-microgram range.
The Sibarov neural-activity work used intranasal administration in rats (PMID 17955380), extending the administration-route framework beyond subcutaneous. Research-supply protocols typically use subcutaneous administration at dose tiers extrapolated from the rodent-model framework.
The compound’s research base is concentrated within a single research lineage, which limits the dose-range characterisation compared to compounds with broader cross-laboratory replication. Researchers should anchor protocol design to the specific Khavinson or Anisimov publication being replicated rather than treating the literature as fully cross-validated.
Why this matters in research context
Epithalon’s dose framework is narrower than the broader catalog peptide-research compounds because the research literature is concentrated within a single research lineage. Researchers selecting Epithalon should anchor protocol design to the specific published context and apply appropriate caveats about extrapolation.
Related compounds
- Epithalon 10mg — the compound covered by this answer
Related research questions
References
- Khavinson VK et al. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev 2000;120(1-3):141-149. [PMID 11087911]
- Anisimov VN et al. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett 2002;183(1):1-8. [PMID 12049808]
- Kossoy G et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo 2006;20(2):253-257. [PMID 16634527]
- Sibarov DA et al. Effects of intranasal administration of epitalon on neuron activity in the rat neocortex. Neurosci Behav Physiol 2007;37(9):887-893. [PMID 17955380]
Research-questions pages describe research-context use of peptide-research terminology. They do not constitute medical, veterinary, or clinical advice. Epithalon is sold strictly as a research-grade reagent for laboratory and bench research applications.